5. Fibrocystic Breast Disease
Although this does not necessarily refer to coffee on an empty stomach, it is nevertheless essential. The Journal of the National Cancer Institute has reported an association between caffeine consumption and breast fibrocystic breast disease (FBD).
If you drink between 31 and 250 mg of caffeine a day, the risk of developing the disease increased 1.5-fold, if you drink more than 500 mg, the risk of developing the disease increased 2.3-fold.